Aurora-A Induces Chemoresistance Through Activation of the AKT/mTOR Pathway in Endometrial Cancer

Aurora-A Induces Chemoresistance Through Activation of the AKT/mTOR Pathway in Endometrial Cancer

Endometrial cancer (EC) is the most common gynecological tumor all over the world, and advanced/metastatic EC remains a malignancy with poor survival outcome due to highly resistant to conventional chemotherapeutic treatment. Here, we report that Aurora-A, a serine-threonine kinase, plays a vital ro...

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Bibliographic Details
Main Authors: Jun Wu, Ziyun Cheng, Xiaofeng Xu, Jian Fu, Kaiyue Wang, Tao Liu, Chan Wu, Xiangyi Kong, Qian Yang, Guijun Yan, Huaijun Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Oncology
Subjects:
AKT signaling
Aurora-A
Chemoresistance
Endometrial cancer
mTOR signaling
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00422/full

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