Genome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation.

Genome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation.

Glycosylation is a fundamental modification of proteins and membrane lipids. Toxins that utilize glycans as their receptors have served as powerful tools to identify key players in glycosylation processes. Here, we carried out Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9-m...

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Bibliographic Details
Main Authors: Songhai Tian, Khaja Muneeruddin, Mei Yuk Choi, Liang Tao, Robiul H Bhuiyan, Yuhsuke Ohmi, Keiko Furukawa, Koichi Furukawa, Sebastian Boland, Scott A Shaffer, Rosalyn M Adam, Min Dong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-11-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC6258472?pdf=render

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