Abnormal expression of ATP1A1 and ATP1A2 in breast cancer [version 1; referees: 2 approved]

Abnormal expression of ATP1A1 and ATP1A2 in breast cancer [version 1; referees: 2 approved]

Breast cancer is the first in incidence and the second in death among all solid tumors occurring in women. The identification of molecular genetic abnormalities in breast cancer is important to improve the results of treatment. In the present study, we analyzed microarray data of breast cancer expre...

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Main Authors: Alexey Bogdanov, Fedor Moiseenko, Michael Dubina
Format: Article
Language:English
Published: F1000 Research Ltd 2017-01-01
Series:F1000Research
Subjects:
Breast Diseases: Benign & Malignant
Online Access:https://f1000research.com/articles/6-10/v1
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spelling doaj-0f4751e011f744139cbbea24f4f8a7bb2020-11-25T03:18:29ZengF1000 Research LtdF1000Research2046-14022017-01-01610.12688/f1000research.10481.111294Abnormal expression of ATP1A1 and ATP1A2 in breast cancer [version 1; referees: 2 approved]Alexey Bogdanov0Fedor Moiseenko1Michael Dubina2The Petersburg Nuclear Physics Institute, Gatchina, Russian FederationPractical Center for Specialized Types of Medical Care (Oncologic), St-Petersburg, Russian FederationPeter the Great St. Petersburg Polytechnic University, St. Petersburg, Russian FederationBreast cancer is the first in incidence and the second in death among all solid tumors occurring in women. The identification of molecular genetic abnormalities in breast cancer is important to improve the results of treatment. In the present study, we analyzed microarray data of breast cancer expression profiling (NCBI GEO database, accession GSE65194), focusing on Na+/K+-ATPase coding genes. We found overexpression of the ATP1A1 and down-regulation of the ATP1A2. We expect that our research could help to improve the understanding of predictive and prognostic features of breast cancer.https://f1000research.com/articles/6-10/v1Breast Diseases: Benign & Malignant
collection DOAJ
language English
format Article
sources DOAJ
author Alexey Bogdanov
Fedor Moiseenko
Michael Dubina
spellingShingle Alexey Bogdanov
Fedor Moiseenko
Michael Dubina
Abnormal expression of ATP1A1 and ATP1A2 in breast cancer [version 1; referees: 2 approved]
F1000Research
Breast Diseases: Benign & Malignant
author_facet Alexey Bogdanov
Fedor Moiseenko
Michael Dubina
author_sort Alexey Bogdanov
title Abnormal expression of ATP1A1 and ATP1A2 in breast cancer [version 1; referees: 2 approved]
title_short Abnormal expression of ATP1A1 and ATP1A2 in breast cancer [version 1; referees: 2 approved]
title_full Abnormal expression of ATP1A1 and ATP1A2 in breast cancer [version 1; referees: 2 approved]
title_fullStr Abnormal expression of ATP1A1 and ATP1A2 in breast cancer [version 1; referees: 2 approved]
title_full_unstemmed Abnormal expression of ATP1A1 and ATP1A2 in breast cancer [version 1; referees: 2 approved]
title_sort abnormal expression of atp1a1 and atp1a2 in breast cancer [version 1; referees: 2 approved]
publisher F1000 Research Ltd
series F1000Research
issn 2046-1402
publishDate 2017-01-01
description Breast cancer is the first in incidence and the second in death among all solid tumors occurring in women. The identification of molecular genetic abnormalities in breast cancer is important to improve the results of treatment. In the present study, we analyzed microarray data of breast cancer expression profiling (NCBI GEO database, accession GSE65194), focusing on Na+/K+-ATPase coding genes. We found overexpression of the ATP1A1 and down-regulation of the ATP1A2. We expect that our research could help to improve the understanding of predictive and prognostic features of breast cancer.
topic Breast Diseases: Benign & Malignant
url https://f1000research.com/articles/6-10/v1
work_keys_str_mv AT alexeybogdanov abnormalexpressionofatp1a1andatp1a2inbreastcancerversion1referees2approved
AT fedormoiseenko abnormalexpressionofatp1a1andatp1a2inbreastcancerversion1referees2approved
AT michaeldubina abnormalexpressionofatp1a1andatp1a2inbreastcancerversion1referees2approved
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