Effects of Anti-TNF Alpha Drugs on Disability in Patients with Rheumatoid Arthritis: Long-Term Real-Life Data from the Lorhen Registry

Effects of Anti-TNF Alpha Drugs on Disability in Patients with Rheumatoid Arthritis: Long-Term Real-Life Data from the Lorhen Registry

This study involving 1033 patients with RA confirms the effectiveness of etanercept, adalimumab, and infliximab in reducing RA-related disability even in patients with a history of highly active and longstanding RA. Moreover, we found that the improvement in disability was biphasic, with a marked im...

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Main Authors: Matteo Filippini, Chiara Bazzani, Fabiola Atzeni, Piercarlo Sarzi Puttini, Antonio Marchesoni, Ennio Giulio Favalli, Roberto Caporali, Lorenzo Cavagna, Roberto Gorla
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2014/416892
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spelling doaj-0f412178fc7840eea9d30f1f5631a31d2020-11-24T22:07:59ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/416892416892Effects of Anti-TNF Alpha Drugs on Disability in Patients with Rheumatoid Arthritis: Long-Term Real-Life Data from the Lorhen RegistryMatteo Filippini0Chiara Bazzani1Fabiola Atzeni2Piercarlo Sarzi Puttini3Antonio Marchesoni4Ennio Giulio Favalli5Roberto Caporali6Lorenzo Cavagna7Roberto Gorla8Rheumatology and Immunology Unit, Spedali Civili di Brescia, Piazza le Spedali Civili 1, 125123 Brescia, ItalyRheumatology and Immunology Unit, Spedali Civili di Brescia, Piazza le Spedali Civili 1, 125123 Brescia, ItalyRheumatology Unit, L. Sacco University Hospital, Via G.B.Grassi 74, 20157 Milan, ItalyRheumatology Unit, L. Sacco University Hospital, Via G.B.Grassi 74, 20157 Milan, ItalyRheumatology Day Hospital, G. Pini Orthopedic Institute, Milan University, Piazza Ferraari, 20122 Milan, ItalyRheumatology Day Hospital, G. Pini Orthopedic Institute, Milan University, Piazza Ferraari, 20122 Milan, ItalyRheumatology Division, University and IRCCS Policlinico S. Matteo Foundation, Piazzale Golgi 2, 27100 Pavia, ItalyRheumatology Division, University and IRCCS Policlinico S. Matteo Foundation, Piazzale Golgi 2, 27100 Pavia, ItalyRheumatology and Immunology Unit, Spedali Civili di Brescia, Piazza le Spedali Civili 1, 125123 Brescia, ItalyThis study involving 1033 patients with RA confirms the effectiveness of etanercept, adalimumab, and infliximab in reducing RA-related disability even in patients with a history of highly active and longstanding RA. Moreover, we found that the improvement in disability was biphasic, with a marked improvement during the first year of anti-TNF therapy, followed by slower but significant recovery over the subsequent four years.http://dx.doi.org/10.1155/2014/416892
collection DOAJ
language English
format Article
sources DOAJ
author Matteo Filippini
Chiara Bazzani
Fabiola Atzeni
Piercarlo Sarzi Puttini
Antonio Marchesoni
Ennio Giulio Favalli
Roberto Caporali
Lorenzo Cavagna
Roberto Gorla
spellingShingle Matteo Filippini
Chiara Bazzani
Fabiola Atzeni
Piercarlo Sarzi Puttini
Antonio Marchesoni
Ennio Giulio Favalli
Roberto Caporali
Lorenzo Cavagna
Roberto Gorla
Effects of Anti-TNF Alpha Drugs on Disability in Patients with Rheumatoid Arthritis: Long-Term Real-Life Data from the Lorhen Registry
BioMed Research International
author_facet Matteo Filippini
Chiara Bazzani
Fabiola Atzeni
Piercarlo Sarzi Puttini
Antonio Marchesoni
Ennio Giulio Favalli
Roberto Caporali
Lorenzo Cavagna
Roberto Gorla
author_sort Matteo Filippini
title Effects of Anti-TNF Alpha Drugs on Disability in Patients with Rheumatoid Arthritis: Long-Term Real-Life Data from the Lorhen Registry
title_short Effects of Anti-TNF Alpha Drugs on Disability in Patients with Rheumatoid Arthritis: Long-Term Real-Life Data from the Lorhen Registry
title_full Effects of Anti-TNF Alpha Drugs on Disability in Patients with Rheumatoid Arthritis: Long-Term Real-Life Data from the Lorhen Registry
title_fullStr Effects of Anti-TNF Alpha Drugs on Disability in Patients with Rheumatoid Arthritis: Long-Term Real-Life Data from the Lorhen Registry
title_full_unstemmed Effects of Anti-TNF Alpha Drugs on Disability in Patients with Rheumatoid Arthritis: Long-Term Real-Life Data from the Lorhen Registry
title_sort effects of anti-tnf alpha drugs on disability in patients with rheumatoid arthritis: long-term real-life data from the lorhen registry
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2014-01-01
description This study involving 1033 patients with RA confirms the effectiveness of etanercept, adalimumab, and infliximab in reducing RA-related disability even in patients with a history of highly active and longstanding RA. Moreover, we found that the improvement in disability was biphasic, with a marked improvement during the first year of anti-TNF therapy, followed by slower but significant recovery over the subsequent four years.
url http://dx.doi.org/10.1155/2014/416892
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