Parallel Synthesis of a Library of Symmetrically- and Dissymmetrically-disubstituted Imidazole-4,5-dicarboxamides Bearing Amino Acid Esters

Parallel Synthesis of a Library of Symmetrically- and Dissymmetrically-disubstituted Imidazole-4,5-dicarboxamides Bearing Amino Acid Esters

The imidazole-4,5-dicarboxylic acid scaffold is readily derivatized with amino acid esters to afford symmetrically- and dissymmetrically-disubstituted imidazole-4,5-dicarboxamides with intramolecularly hydrogen bonded conformations that predispose the presentation of amino acid pharmacophores. In th...

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Bibliographic Details
Main Authors: Rosanna Solinas, John C. DiCesare, Paul W. Baures
Format: Article
Language:English
Published: MDPI AG 2009-01-01
Series:Molecules
Subjects:
Imidazole
NIH Roadmap
Heterocyclic scaffold
Drug discovery
Online Access:http://www.mdpi.com/1420-3049/14/1/352/

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