The pan HDAC inhibitor Givinostat improves muscle function and histological parameters in two Duchenne muscular dystrophy murine models expressing different haplotypes of the LTBP4 gene

The pan HDAC inhibitor Givinostat improves muscle function and histological parameters in two Duchenne muscular dystrophy murine models expressing different haplotypes of the LTBP4 gene

Abstract Background In the search of genetic determinants of Duchenne muscular dystrophy (DMD) severity, LTBP4, a member of the latent TGF-β binding protein family, emerged as an important predictor of functional outcome trajectories in mice and humans. Nonsynonymous single-nucleotide polymorphisms...

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Bibliographic Details
Main Authors: Simonetta Andrea Licandro, Luca Crippa, Roberta Pomarico, Raffaella Perego, Gianluca Fossati, Flavio Leoni, Christian Steinkühler
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Skeletal Muscle
Subjects:
Duchenne nuscular dystrophy
Givinostat
mdx
D2.B10
LTBP4
HDAC inhibitor
Online Access:https://doi.org/10.1186/s13395-021-00273-6

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