THE ROLE OF HYPERINSULINEMIA AND INSULIN RESISTANCE IN DEVELOPMENT OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH METABOLIC SYNDROME

• Main Authors: I M Kutyrina, A A Kryachkova, S A Savelieva
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2012-06-01
• Series: Терапевтический архив
• Subjects: chronic kidney disease; insulin resistance
• Online Access: https://ter-arkhiv.ru/0040-3660/article/view/31042

Aim. To examine relations between hyperinsulinemia, insulin resistance (IR), components of metabolic syndrome (MS) and predisposition to renal damage. Material and methods. A total of 94 MS patients (64 males and 30 females, age 30-67 years, mean age 52±9 years) entered the study. The examination included measurement of waist and hip circumference, body mass index (BMI), HOMA index, estimation of lipids and immunoreactive insulin concentrations. Renal damage was assessed by glomerular filtration rate and urinary excretion of albumin. The patients were divided into groups by IR and BMI. Results. A strong correlation was found between IR markers and lipid metabolism disorders, hemodynamic parameters. Statistics show that IR is an independent unfavourable factor of renal damage in MS patients. Conclusion. IR is an essential component of MS and an independent factor of development of chronic kidney disease in MS patients.