Low-dose methotrexate in sickle-cell disease: a pilot study with rationale borrowed from rheumatoid arthritis

Low-dose methotrexate in sickle-cell disease: a pilot study with rationale borrowed from rheumatoid arthritis

Abstract Background Inflammation is a major feature of sickle cell disease (SCD). Low-dose methotrexate (MTX) has long been used in chronic inflammatory diseases. This pilot study examined the MTX effect on acute vaso-occlusive pain crises (VOC) in SCD patients. Methods Fourteen adults on hydroxyure...

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Bibliographic Details
Main Authors: Silvia R. Brandalise, Rosemary Assis, Angelo B. A. Laranjeira, José Andrés Yunes, Pedro O. de Campos-Lima
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Experimental Hematology & Oncology
Subjects:
Sickle cell disease
Methotrexate
Inflammation
Pain
Chemokines
Online Access:http://link.springer.com/article/10.1186/s40164-017-0078-1

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