Modulation of the Cardiomyocyte Contraction inside a Hydrostatic Pressure Bioreactor: In Vitro Verification of the Frank-Starling Law

Modulation of the Cardiomyocyte Contraction inside a Hydrostatic Pressure Bioreactor: In Vitro Verification of the Frank-Starling Law

We have studied beating mouse cardiac syncytia in vitro in order to assess the inotropic, ergotropic, and chronotropic effects of both increasing and decreasing hydrostatic pressures. In particular, we have performed an image processing analysis to evaluate the kinematics and the dynamics of those p...

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Main Authors: Lorenzo Fassina, Giovanni Magenes, Roberto Gimmelli, Fabio Naro
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2015/542105
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spelling doaj-0f1f004e19774c42b41ef1c68f7fe9212020-11-24T23:59:45ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/542105542105Modulation of the Cardiomyocyte Contraction inside a Hydrostatic Pressure Bioreactor: In Vitro Verification of the Frank-Starling LawLorenzo Fassina0Giovanni Magenes1Roberto Gimmelli2Fabio Naro3Dipartimento di Ingegneria Industriale e dell’Informazione, Università di Pavia, Via Ferrata 1, 27100 Pavia, ItalyDipartimento di Ingegneria Industriale e dell’Informazione, Università di Pavia, Via Ferrata 1, 27100 Pavia, ItalyDipartimento di Medicina Sperimentale, Università “Sapienza”, 00161 Roma, ItalyDipartimento di Scienze Anatomiche, Istologiche, Medico-Legali e dell’Apparato Locomotore, Università “Sapienza”, 00161 Roma, ItalyWe have studied beating mouse cardiac syncytia in vitro in order to assess the inotropic, ergotropic, and chronotropic effects of both increasing and decreasing hydrostatic pressures. In particular, we have performed an image processing analysis to evaluate the kinematics and the dynamics of those pressure-loaded beating syncytia starting from the video registration of their contraction movement. By this analysis, we have verified the Frank-Starling law of the heart in in vitro beating cardiac syncytia and we have obtained their geometrical-functional classification.http://dx.doi.org/10.1155/2015/542105
collection DOAJ
language English
format Article
sources DOAJ
author Lorenzo Fassina
Giovanni Magenes
Roberto Gimmelli
Fabio Naro
spellingShingle Lorenzo Fassina
Giovanni Magenes
Roberto Gimmelli
Fabio Naro
Modulation of the Cardiomyocyte Contraction inside a Hydrostatic Pressure Bioreactor: In Vitro Verification of the Frank-Starling Law
BioMed Research International
author_facet Lorenzo Fassina
Giovanni Magenes
Roberto Gimmelli
Fabio Naro
author_sort Lorenzo Fassina
title Modulation of the Cardiomyocyte Contraction inside a Hydrostatic Pressure Bioreactor: In Vitro Verification of the Frank-Starling Law
title_short Modulation of the Cardiomyocyte Contraction inside a Hydrostatic Pressure Bioreactor: In Vitro Verification of the Frank-Starling Law
title_full Modulation of the Cardiomyocyte Contraction inside a Hydrostatic Pressure Bioreactor: In Vitro Verification of the Frank-Starling Law
title_fullStr Modulation of the Cardiomyocyte Contraction inside a Hydrostatic Pressure Bioreactor: In Vitro Verification of the Frank-Starling Law
title_full_unstemmed Modulation of the Cardiomyocyte Contraction inside a Hydrostatic Pressure Bioreactor: In Vitro Verification of the Frank-Starling Law
title_sort modulation of the cardiomyocyte contraction inside a hydrostatic pressure bioreactor: in vitro verification of the frank-starling law
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2015-01-01
description We have studied beating mouse cardiac syncytia in vitro in order to assess the inotropic, ergotropic, and chronotropic effects of both increasing and decreasing hydrostatic pressures. In particular, we have performed an image processing analysis to evaluate the kinematics and the dynamics of those pressure-loaded beating syncytia starting from the video registration of their contraction movement. By this analysis, we have verified the Frank-Starling law of the heart in in vitro beating cardiac syncytia and we have obtained their geometrical-functional classification.
url http://dx.doi.org/10.1155/2015/542105
work_keys_str_mv AT lorenzofassina modulationofthecardiomyocytecontractioninsideahydrostaticpressurebioreactorinvitroverificationofthefrankstarlinglaw
AT giovannimagenes modulationofthecardiomyocytecontractioninsideahydrostaticpressurebioreactorinvitroverificationofthefrankstarlinglaw
AT robertogimmelli modulationofthecardiomyocytecontractioninsideahydrostaticpressurebioreactorinvitroverificationofthefrankstarlinglaw
AT fabionaro modulationofthecardiomyocytecontractioninsideahydrostaticpressurebioreactorinvitroverificationofthefrankstarlinglaw
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