Position for Site-Specific Attachment of a DOTA Chelator to Synthetic Affibody Molecules Has a Different Influence on the Targeting Properties of Ga-Compared to In-Labeled Conjugates

Position for Site-Specific Attachment of a DOTA Chelator to Synthetic Affibody Molecules Has a Different Influence on the Targeting Properties of Ga-Compared to In-Labeled Conjugates

Affibody molecules, small (7 kDa) scaffold proteins, are a promising class of probes for radionuclide molecular imaging. Radiolabeling of Affibody molecules with the positron-emitting nuclide 68 Ga would permit the use of positron emission tomography (PET), providing better resolution, sensitivity,...

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Bibliographic Details
Main Authors: Hadis Honarvar, Joanna Strand, Anna Perols, Anna Orlova, Ram Kumar Selvaraju, Amelie Eriksson Karlström, Vladimir Tolmachev
Format: Article
Language:English
Published: Hindawi - SAGE Publishing 2014-12-01
Series:Molecular Imaging
Online Access:https://doi.org/10.2310/7290.2014.00034

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