Global and regional degree of obstruction determined by electrical impedance tomography in patients with obstructive ventilatory defect.

BACKGROUND:Electrical impedance tomography is a continuous imaging method capable of measuring lung volume changes. The purpose of this study was to examine whether EIT was capable of evaluating the degree of obstructive ventilatory defect (OVD) on the global and regional level. METHODS:41 healthy s...

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Main Authors: Chao Zhang, Meng Dai, Wei Liu, Xiaohui Bai, Jiaming Wu, Canhua Xu, Junying Xia, Feng Fu, Xuetao Shi, Xiuzhen Dong, Faguang Jin, Fusheng You
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0209473
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spelling doaj-0f18f32236e34e3891534c7a6c7d812c2021-03-03T21:01:10ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011312e020947310.1371/journal.pone.0209473Global and regional degree of obstruction determined by electrical impedance tomography in patients with obstructive ventilatory defect.Chao ZhangMeng DaiWei LiuXiaohui BaiJiaming WuCanhua XuJunying XiaFeng FuXuetao ShiXiuzhen DongFaguang JinFusheng YouBACKGROUND:Electrical impedance tomography is a continuous imaging method capable of measuring lung volume changes. The purpose of this study was to examine whether EIT was capable of evaluating the degree of obstructive ventilatory defect (OVD) on the global and regional level. METHODS:41 healthy subjects with no lung diseases and 67 subjects suffering from obstructive lung diseases were examined using EIT and spirometry during forced vital capacity (FVC) maneuver. The subjects were divided into control group (n = 41), early airway obstruction group (n = 26), mild group (n = 17), moderate group (n = 16) and severe group (n = 8) according to the degree of obstruction. Forced expiratory volume in 1 second (FEV1) and FEV1/FVC were determined by EIT. The mode index (MI) was proposed to evaluate the degree of global and regional obstruction; the effectiveness of MI was validated by evaluating posture related change of lung emptying capacity in sitting and supine postures; the degree of regional obstruction was determined according to the cut-off values of MI obtained from receiver operating characteristic (ROC) analysis; regional obstruction was located in the four-quadrant region of interest (ROI) and the contour-map ROI with contour lines at the cut-off values of MI. RESULTS:Significant differences were found between different groups (P<0.05) and the global MI was 0.93±0.03, 0.86±0.05, 0.81±0.09, 0.73±0.09 and 0.60±0.11 (mean ±SD), respectively. The cut-off MI value was 0.90, 0.83, 0.77, and 0.65, respectively. CONCLUSION:The results indicated the potential of EIT to evaluate the degree of obstruction in patients with obstructive ventilatory defect on the global and regional level.https://doi.org/10.1371/journal.pone.0209473
collection DOAJ
language English
format Article
sources DOAJ
author Chao Zhang
Meng Dai
Wei Liu
Xiaohui Bai
Jiaming Wu
Canhua Xu
Junying Xia
Feng Fu
Xuetao Shi
Xiuzhen Dong
Faguang Jin
Fusheng You
spellingShingle Chao Zhang
Meng Dai
Wei Liu
Xiaohui Bai
Jiaming Wu
Canhua Xu
Junying Xia
Feng Fu
Xuetao Shi
Xiuzhen Dong
Faguang Jin
Fusheng You
Global and regional degree of obstruction determined by electrical impedance tomography in patients with obstructive ventilatory defect.
PLoS ONE
author_facet Chao Zhang
Meng Dai
Wei Liu
Xiaohui Bai
Jiaming Wu
Canhua Xu
Junying Xia
Feng Fu
Xuetao Shi
Xiuzhen Dong
Faguang Jin
Fusheng You
author_sort Chao Zhang
title Global and regional degree of obstruction determined by electrical impedance tomography in patients with obstructive ventilatory defect.
title_short Global and regional degree of obstruction determined by electrical impedance tomography in patients with obstructive ventilatory defect.
title_full Global and regional degree of obstruction determined by electrical impedance tomography in patients with obstructive ventilatory defect.
title_fullStr Global and regional degree of obstruction determined by electrical impedance tomography in patients with obstructive ventilatory defect.
title_full_unstemmed Global and regional degree of obstruction determined by electrical impedance tomography in patients with obstructive ventilatory defect.
title_sort global and regional degree of obstruction determined by electrical impedance tomography in patients with obstructive ventilatory defect.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2018-01-01
description BACKGROUND:Electrical impedance tomography is a continuous imaging method capable of measuring lung volume changes. The purpose of this study was to examine whether EIT was capable of evaluating the degree of obstructive ventilatory defect (OVD) on the global and regional level. METHODS:41 healthy subjects with no lung diseases and 67 subjects suffering from obstructive lung diseases were examined using EIT and spirometry during forced vital capacity (FVC) maneuver. The subjects were divided into control group (n = 41), early airway obstruction group (n = 26), mild group (n = 17), moderate group (n = 16) and severe group (n = 8) according to the degree of obstruction. Forced expiratory volume in 1 second (FEV1) and FEV1/FVC were determined by EIT. The mode index (MI) was proposed to evaluate the degree of global and regional obstruction; the effectiveness of MI was validated by evaluating posture related change of lung emptying capacity in sitting and supine postures; the degree of regional obstruction was determined according to the cut-off values of MI obtained from receiver operating characteristic (ROC) analysis; regional obstruction was located in the four-quadrant region of interest (ROI) and the contour-map ROI with contour lines at the cut-off values of MI. RESULTS:Significant differences were found between different groups (P<0.05) and the global MI was 0.93±0.03, 0.86±0.05, 0.81±0.09, 0.73±0.09 and 0.60±0.11 (mean ±SD), respectively. The cut-off MI value was 0.90, 0.83, 0.77, and 0.65, respectively. CONCLUSION:The results indicated the potential of EIT to evaluate the degree of obstruction in patients with obstructive ventilatory defect on the global and regional level.
url https://doi.org/10.1371/journal.pone.0209473
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