Spatial constraints govern competition of mutant clones in human epidermis

Spatial constraints govern competition of mutant clones in human epidermis

Deep sequencing technologies allow for the investigation of clonal evolution in human cancers. Here the authors, combining sequencing data from human skin with mathematical modelling and simulations, suggest that the spatial context of a mutation with respect to other mutant clones may lead to diffe...

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Main Authors: M. D. Lynch, C. N. S. Lynch, E. Craythorne, K. Liakath-Ali, R. Mallipeddi, J. N. Barker, F. M. Watt
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00993-8
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spelling doaj-0f0d3a09923e4b6eb97e3107824208bf2021-05-11T07:17:38ZengNature Publishing GroupNature Communications2041-17232017-10-018111110.1038/s41467-017-00993-8Spatial constraints govern competition of mutant clones in human epidermisM. D. Lynch0C. N. S. Lynch1E. Craythorne2K. Liakath-Ali3R. Mallipeddi4J. N. Barker5F. M. Watt6Centre for Stem Cells and Regenerative Medicine, King’s College LondonCentre for Stem Cells and Regenerative Medicine, King’s College LondonSt John’s Institute of Dermatology, King’s College LondonCentre for Stem Cells and Regenerative Medicine, King’s College LondonSt John’s Institute of Dermatology, King’s College LondonSt John’s Institute of Dermatology, King’s College LondonCentre for Stem Cells and Regenerative Medicine, King’s College LondonDeep sequencing technologies allow for the investigation of clonal evolution in human cancers. Here the authors, combining sequencing data from human skin with mathematical modelling and simulations, suggest that the spatial context of a mutation with respect to other mutant clones may lead to differential clonal evolution.https://doi.org/10.1038/s41467-017-00993-8
collection DOAJ
language English
format Article
sources DOAJ
author M. D. Lynch
C. N. S. Lynch
E. Craythorne
K. Liakath-Ali
R. Mallipeddi
J. N. Barker
F. M. Watt
spellingShingle M. D. Lynch
C. N. S. Lynch
E. Craythorne
K. Liakath-Ali
R. Mallipeddi
J. N. Barker
F. M. Watt
Spatial constraints govern competition of mutant clones in human epidermis
Nature Communications
author_facet M. D. Lynch
C. N. S. Lynch
E. Craythorne
K. Liakath-Ali
R. Mallipeddi
J. N. Barker
F. M. Watt
author_sort M. D. Lynch
title Spatial constraints govern competition of mutant clones in human epidermis
title_short Spatial constraints govern competition of mutant clones in human epidermis
title_full Spatial constraints govern competition of mutant clones in human epidermis
title_fullStr Spatial constraints govern competition of mutant clones in human epidermis
title_full_unstemmed Spatial constraints govern competition of mutant clones in human epidermis
title_sort spatial constraints govern competition of mutant clones in human epidermis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-10-01
description Deep sequencing technologies allow for the investigation of clonal evolution in human cancers. Here the authors, combining sequencing data from human skin with mathematical modelling and simulations, suggest that the spatial context of a mutation with respect to other mutant clones may lead to differential clonal evolution.
url https://doi.org/10.1038/s41467-017-00993-8
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