Evaluation of Herpes Simplex Virus IgG Specific Antibody and high-sensitivity C-Reactive Protein Levels in Patients with Coronary Artery Disease

• Main Authors: Mohammad Taleb Jannesar Hosseini, Maryam Ghane
• Format: Article
• Language: English
• Published: Farname 2018-04-01
• Series: Iranian Journal of Medical Microbiology
• Subjects: Atherosclerosis; Herpes Simplex Virus; C-Reactive Protein
• Online Access: http://ijmm.ir/article-1-789-en.html

Background and Aims: Coronary artery disease (CAD) is a major cause of mortality worldwide. Infectious agents such as herpes simplex virus (HSV) may be implicated in the pathogenesis of atherosclerosis. The aim of this study was to survey the prevalence of IgG antibodies against HSV in patients with coronary artery disease and to determine the mean of high-sensitivity C-reactive protein(hs-CRP) in these patients. Materials and Methods: 40 patients being evaluated for atherosclerosis by coronary angiography along with 40 healthy individuals as a control group were examined in this research. Assessment of hs-CRP was carried out by nephelometry and virus-specific IgG antibodies by Enzyme-linked Immunosorbent Assay (ELISA). Results and Conclusions: Results showed that the levels of hs-CRP were significantly higher among patients compared to that of control group (P<0.05). Higher percentage of patients had anti-HSV (78.4%) compared to healthy individuals (21.6%). Significant correlation was detected between HSV seropositivity and CAD. The mean of hs-CRP was significantly higher in subjects with HSV positive serology. In conclusion, the seropositivity of HSV along with high levels of hs-CRP may be a risk factor for coronary atherosclerosis.