Mechanistic Insights Into MicroRNA-Induced Neuronal Reprogramming of Human Adult Fibroblasts

Mechanistic Insights Into MicroRNA-Induced Neuronal Reprogramming of Human Adult Fibroblasts

The use of transcriptional factors as cell fate regulators are often the primary focus in the direct reprogramming of somatic cells into neurons. However, in human adult fibroblasts, deriving functionally mature neurons with high efficiency requires additional neurogenic factors such as microRNAs (m...

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Bibliographic Details
Main Authors: Ya-Lin Lu, Andrew S. Yoo
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Neuroscience
Subjects:
microRNA
chromatin
neuronal conversion
reprogramming
neurogenesis
disease modeling
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00522/full

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