The Effect of Small Cosolutes that Mimic Molecular Crowding Conditions on the Stability of Triplexes Involving Duplex DNA

The Effect of Small Cosolutes that Mimic Molecular Crowding Conditions on the Stability of Triplexes Involving Duplex DNA

Triplex stability is studied in crowding conditions using small cosolutes (ethanol, acetonitrile and dimethylsulfoxide) by ultraviolet (UV), circular dichroism (CD) and nuclear magnetic resonance (NMR) spectroscopies. The results indicate that the triplex is formed preferentially when the triplex fo...

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Bibliographic Details
Main Authors: Anna Aviñó, Stefania Mazzini, Raimundo Gargallo, Ramon Eritja
Format: Article
Language:English
Published: MDPI AG 2016-02-01
Series:International Journal of Molecular Sciences
Subjects:
molecular crowding
triplex forming oligonucleotide (TFO)
DNA
RNA
cosolute
thermal stability
Online Access:http://www.mdpi.com/1422-0067/17/2/211

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