The Metallome as a Link Between the “Omes” in Autism Spectrum Disorders

Metal dyshomeostasis plays a significant role in various neurological diseases such as Alzheimer’s disease, Parkinson’s disease, Autism Spectrum Disorders (ASD), and many more. Like studies investigating the proteome, transcriptome, epigenome, microbiome, etc., for years, metallomics studies have fo...

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Main Authors: Janelle E. Stanton, Sigita Malijauskaite, Kieran McGourty, Andreas M. Grabrucker
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.695873/full
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spelling doaj-0ee9aa408bf7440d82f43e56389c92cf2021-07-05T06:03:27ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992021-07-011410.3389/fnmol.2021.695873695873The Metallome as a Link Between the “Omes” in Autism Spectrum DisordersJanelle E. Stanton0Janelle E. Stanton1Sigita Malijauskaite2Sigita Malijauskaite3Kieran McGourty4Kieran McGourty5Kieran McGourty6Andreas M. Grabrucker7Andreas M. Grabrucker8Andreas M. Grabrucker9Department of Biological Sciences, University of Limerick, Limerick, IrelandBernal Institute, University of Limerick, Limerick, IrelandBernal Institute, University of Limerick, Limerick, IrelandDepartment of Chemical Sciences, University of Limerick, Limerick, IrelandBernal Institute, University of Limerick, Limerick, IrelandDepartment of Chemical Sciences, University of Limerick, Limerick, IrelandHealth Research Institute, University of Limerick, Limerick, IrelandDepartment of Biological Sciences, University of Limerick, Limerick, IrelandBernal Institute, University of Limerick, Limerick, IrelandHealth Research Institute, University of Limerick, Limerick, IrelandMetal dyshomeostasis plays a significant role in various neurological diseases such as Alzheimer’s disease, Parkinson’s disease, Autism Spectrum Disorders (ASD), and many more. Like studies investigating the proteome, transcriptome, epigenome, microbiome, etc., for years, metallomics studies have focused on data from their domain, i.e., trace metal composition, only. Still, few have considered the links between other “omes,” which may together result in an individual’s specific pathologies. In particular, ASD have been reported to have multitudes of possible causal effects. Metallomics data focusing on metal deficiencies and dyshomeostasis can be linked to functions of metalloenzymes, metal transporters, and transcription factors, thus affecting the proteome and transcriptome. Furthermore, recent studies in ASD have emphasized the gut-brain axis, with alterations in the microbiome being linked to changes in the metabolome and inflammatory processes. However, the microbiome and other “omes” are heavily influenced by the metallome. Thus, here, we will summarize the known implications of a changed metallome for other “omes” in the body in the context of “omics” studies in ASD. We will highlight possible connections and propose a model that may explain the so far independently reported pathologies in ASD.https://www.frontiersin.org/articles/10.3389/fnmol.2021.695873/fullautismmetallomezinc deficiencyinflammationmicrobiomeproteome
collection DOAJ
language English
format Article
sources DOAJ
author Janelle E. Stanton
Janelle E. Stanton
Sigita Malijauskaite
Sigita Malijauskaite
Kieran McGourty
Kieran McGourty
Kieran McGourty
Andreas M. Grabrucker
Andreas M. Grabrucker
Andreas M. Grabrucker
spellingShingle Janelle E. Stanton
Janelle E. Stanton
Sigita Malijauskaite
Sigita Malijauskaite
Kieran McGourty
Kieran McGourty
Kieran McGourty
Andreas M. Grabrucker
Andreas M. Grabrucker
Andreas M. Grabrucker
The Metallome as a Link Between the “Omes” in Autism Spectrum Disorders
Frontiers in Molecular Neuroscience
autism
metallome
zinc deficiency
inflammation
microbiome
proteome
author_facet Janelle E. Stanton
Janelle E. Stanton
Sigita Malijauskaite
Sigita Malijauskaite
Kieran McGourty
Kieran McGourty
Kieran McGourty
Andreas M. Grabrucker
Andreas M. Grabrucker
Andreas M. Grabrucker
author_sort Janelle E. Stanton
title The Metallome as a Link Between the “Omes” in Autism Spectrum Disorders
title_short The Metallome as a Link Between the “Omes” in Autism Spectrum Disorders
title_full The Metallome as a Link Between the “Omes” in Autism Spectrum Disorders
title_fullStr The Metallome as a Link Between the “Omes” in Autism Spectrum Disorders
title_full_unstemmed The Metallome as a Link Between the “Omes” in Autism Spectrum Disorders
title_sort metallome as a link between the “omes” in autism spectrum disorders
publisher Frontiers Media S.A.
series Frontiers in Molecular Neuroscience
issn 1662-5099
publishDate 2021-07-01
description Metal dyshomeostasis plays a significant role in various neurological diseases such as Alzheimer’s disease, Parkinson’s disease, Autism Spectrum Disorders (ASD), and many more. Like studies investigating the proteome, transcriptome, epigenome, microbiome, etc., for years, metallomics studies have focused on data from their domain, i.e., trace metal composition, only. Still, few have considered the links between other “omes,” which may together result in an individual’s specific pathologies. In particular, ASD have been reported to have multitudes of possible causal effects. Metallomics data focusing on metal deficiencies and dyshomeostasis can be linked to functions of metalloenzymes, metal transporters, and transcription factors, thus affecting the proteome and transcriptome. Furthermore, recent studies in ASD have emphasized the gut-brain axis, with alterations in the microbiome being linked to changes in the metabolome and inflammatory processes. However, the microbiome and other “omes” are heavily influenced by the metallome. Thus, here, we will summarize the known implications of a changed metallome for other “omes” in the body in the context of “omics” studies in ASD. We will highlight possible connections and propose a model that may explain the so far independently reported pathologies in ASD.
topic autism
metallome
zinc deficiency
inflammation
microbiome
proteome
url https://www.frontiersin.org/articles/10.3389/fnmol.2021.695873/full
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