The Peptidisc, a simple method for stabilizing membrane proteins in detergent-free solution

The Peptidisc, a simple method for stabilizing membrane proteins in detergent-free solution

Membrane proteins are difficult to work with due to their insolubility in aqueous solution and quite often their poor stability in detergent micelles. Here, we present the peptidisc for their facile capture into water-soluble particles. Unlike the nanodisc, which requires scaffold proteins of differ...

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Bibliographic Details
Main Authors: Michael Luke Carlson, John William Young, Zhiyu Zhao, Lucien Fabre, Daniel Jun, Jianing Li, Jun Li, Harveer Singh Dhupar, Irvin Wason, Allan T Mills, J Thomas Beatty, John S Klassen, Isabelle Rouiller, Franck Duong
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-08-01
Series:eLife
Subjects:
peptide
membrane protein
nanoparticles
structural biology
self-assembly
Online Access:https://elifesciences.org/articles/34085

Internet

https://elifesciences.org/articles/34085

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