Deficiency of Mitochondrial Aspartate-Glutamate Carrier 1 Leads to Oligodendrocyte Precursor Cell Proliferation Defects Both In Vitro and In Vivo

Deficiency of Mitochondrial Aspartate-Glutamate Carrier 1 Leads to Oligodendrocyte Precursor Cell Proliferation Defects Both In Vitro and In Vivo

Aspartate-Glutamate Carrier 1 (AGC1) deficiency is a rare neurological disease caused by mutations in the solute carrier family 25, member 12 (<i>SLC25A12</i>) gene, encoding for the mitochondrial aspartate-glutamate carrier isoform 1 (AGC1), a component of the malate&#8722;aspartate...

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Bibliographic Details
Main Authors: Sabrina Petralla, Luis Emiliano Peña-Altamira, Eleonora Poeta, Francesca Massenzio, Marco Virgili, Simona Nicole Barile, Luigi Sbano, Emanuela Profilo, Mariangela Corricelli, Alberto Danese, Carlotta Giorgi, Rita Ostan, Miriam Capri, Paolo Pinton, Ferdinando Palmieri, Francesco Massimo Lasorsa, Barbara Monti
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
mouse model
growth factors
subventricular zone
AGC1 deficiency
mitochondrial disease
Online Access:https://www.mdpi.com/1422-0067/20/18/4486

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