Quality of Life and Utility in Patients with Metastatic Soft Tissue and Bone Sarcoma: The Sarcoma Treatment and Burden of Illness in North America and Europe (SABINE) Study

• Main Authors: Peter Reichardt, Michael Leahy, Xavier Garcia del Muro, Stefano Ferrari, Javier Martin, Hans Gelderblom, Jingshu Wang, Arun Krishna, Jennifer Eriksson, Arthur Staddon, Jean-Yves Blay
• Format: Article
• Language: English
• Published: Hindawi Limited 2012-01-01
• Series: Sarcoma
• Online Access: http://dx.doi.org/10.1155/2012/740279

The aim of the study was to assess health-related quality of life (HRQoL) among metastatic soft tissue (mSTS) or bone sarcoma (mBS) patients who had attained a favourable response to chemotherapy. We employed the EORTC QLQ-C30, the 3-item Cancer-Related Symptoms Questionnaire, and the EQ-5D instrument. HRQoL was evaluated overall and by health state in 120 mSTS/mBS patients enrolled in the SABINE study across nine countries in Europe and North America. Utility was estimated from responses to the EQ-5D instrument using UK population-based weights. The mean EQ-5D utility score was 0.69 for the pooled patient sample with little variation across health states. However, patients with progressive disease reported a clinically significant lower utility (0.56). Among disease symptoms, pain and respiratory symptoms are common. This study showed that mSTS/mBS is associated with reduced HRQoL and utility among patients with metastatic disease.