Human intestinal epithelial and smooth muscle cells are potent producers of IL-6

Human intestinal epithelial and smooth muscle cells are potent producers of IL-6

Background: Interleukin-6 (IL-6), a pluripotent cytokine, has traditionally been considered the product of proinflammatory cells. However, many other cell types have been shown to produce IL-6. Since intestinal inflammation is commonly associated with a vigorous systemic inflammatory response, we hy...

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Bibliographic Details
Main Authors: Edmond K. Ng, Ninder Panesar, Walter E. Longo, Marc J. Shapiro, Donald L. Kaminski, Kym C. Tolman, John E. Mazuski
Format: Article
Language:English
Published: Hindawi Limited 2003-01-01
Series:Mediators of Inflammation
Subjects:
Interleukein-6
Interleukin-1
Tumor necrosis factor
Cytokines
Intestine
Epithelium
Smooth muscle
CCL-241
HISM.
Online Access:http://dx.doi.org/10.1080/0962935031000096917
Description
Summary:Background: Interleukin-6 (IL-6), a pluripotent cytokine, has traditionally been considered the product of proinflammatory cells. However, many other cell types have been shown to produce IL-6. Since intestinal inflammation is commonly associated with a vigorous systemic inflammatory response, we hypothesized that intestinal epithelial and smooth muscle cells might contribute to that response by producing IL-6. We therefore studied the capacity of differentiated human intestinal epithelial and smooth muscle cell lines to produce IL-6 in response to various proinflammatory stimuli.
ISSN:0962-9351
1466-1861

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