Pin1 Binding to Phosphorylated PSD-95 Regulates the Number of Functional Excitatory Synapses

Pin1 Binding to Phosphorylated PSD-95 Regulates the Number of Functional Excitatory Synapses

The post-synaptic density protein 95 (PSD-95) plays a central role in excitatory synapse development and synaptic plasticity. Phosphorylation of the N-terminus of PSD-95 at threonine 19 (T19) and serine 25 (S25) decreases PSD-95 stability at synapses; however, a molecular mechanism linking PSD-95 ph...

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Bibliographic Details
Main Authors: Jary Y. Delgado, Duncan Nall, Paul R. Selvin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
post-synaptic density protein 95
proline-directed phosphorylation
palmitoylation
excitatory synaptic transmission
Pin1
cis–trans isomerization
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00010/full

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