RHAMM-target peptides inhibit invasion of breast cancer cells

RHAMM-target peptides inhibit invasion of breast cancer cells

RHAMM is hyaluronan- receptor with multiple functions in the cell, RHAMM is involved in proliferation, motility, migration, invasion, mitotic spindle formation in tumour cells. Therefore, RHAMM could be a relevant target for molecular targeted therapies against tumors.The role of RHAMM-target peptid...

Full description

Bibliographic Details
Main Author: Akentieva Natalia
Format: Article
Language:English
Published: Sciendo 2017-05-01
Series:The EuroBiotech Journal
Online Access:https://doi.org/10.24190/ISSN2564-615X/2017/02.05
id doaj-0e9ca771252a45eb87ca111d4864bc69
record_format Article
spelling doaj-0e9ca771252a45eb87ca111d4864bc692021-09-05T17:19:35ZengSciendoThe EuroBiotech Journal2564-615X2017-05-011213814810.24190/ISSN2564-615X/2017/02.05RHAMM-target peptides inhibit invasion of breast cancer cellsAkentieva Natalia0Kinetics Chemical and Biological Processes; Institute problems of Chemical Physics RAS, pr.acad. Semenova, 1 Chernogolovka Moscow, Russian FederationRHAMM is hyaluronan- receptor with multiple functions in the cell, RHAMM is involved in proliferation, motility, migration, invasion, mitotic spindle formation in tumour cells. Therefore, RHAMM could be a relevant target for molecular targeted therapies against tumors.The role of RHAMM-target peptides in inhibition invasion for preventing breast cancer has not yet been investigated. Base on this, we analyzed the RHAMM-target peptides for their therapeutic activity against breast cancer cells. In the present study, we examined the effect of RHAMM-target peptides on the invasion of breast cancer cells (MDAMB- 231), using confocal microscopy. We shown that RHAMM-target peptides decreased formation of invadopodia of breast cancer cells. The treatment of breast cancer cells by RHAMM -target peptides inhibited the invasion up to 99 %. Additionally, RHAMM-target peptides induced the morphological changes of of breast cancer cells. Therefore, based on these results, we can conclude that RHAMM-target peptides may be potential anti-cancer agents.https://doi.org/10.24190/ISSN2564-615X/2017/02.05
collection DOAJ
language English
format Article
sources DOAJ
author Akentieva Natalia
spellingShingle Akentieva Natalia
RHAMM-target peptides inhibit invasion of breast cancer cells
The EuroBiotech Journal
author_facet Akentieva Natalia
author_sort Akentieva Natalia
title RHAMM-target peptides inhibit invasion of breast cancer cells
title_short RHAMM-target peptides inhibit invasion of breast cancer cells
title_full RHAMM-target peptides inhibit invasion of breast cancer cells
title_fullStr RHAMM-target peptides inhibit invasion of breast cancer cells
title_full_unstemmed RHAMM-target peptides inhibit invasion of breast cancer cells
title_sort rhamm-target peptides inhibit invasion of breast cancer cells
publisher Sciendo
series The EuroBiotech Journal
issn 2564-615X
publishDate 2017-05-01
description RHAMM is hyaluronan- receptor with multiple functions in the cell, RHAMM is involved in proliferation, motility, migration, invasion, mitotic spindle formation in tumour cells. Therefore, RHAMM could be a relevant target for molecular targeted therapies against tumors.The role of RHAMM-target peptides in inhibition invasion for preventing breast cancer has not yet been investigated. Base on this, we analyzed the RHAMM-target peptides for their therapeutic activity against breast cancer cells. In the present study, we examined the effect of RHAMM-target peptides on the invasion of breast cancer cells (MDAMB- 231), using confocal microscopy. We shown that RHAMM-target peptides decreased formation of invadopodia of breast cancer cells. The treatment of breast cancer cells by RHAMM -target peptides inhibited the invasion up to 99 %. Additionally, RHAMM-target peptides induced the morphological changes of of breast cancer cells. Therefore, based on these results, we can conclude that RHAMM-target peptides may be potential anti-cancer agents.
url https://doi.org/10.24190/ISSN2564-615X/2017/02.05
work_keys_str_mv AT akentievanatalia rhammtargetpeptidesinhibitinvasionofbreastcancercells
_version_ 1717786602386751488

Similar Items