Structural basis for therapeutic inhibition of influenza A polymerase PB2 subunit

Structural basis for therapeutic inhibition of influenza A polymerase PB2 subunit

Abstract Influenza virus uses a unique mechanism to initiate viral transcription named cap-snatching. The PB2 subunit of the viral heterotrimeric RNA polymerase binds the cap structure of cellular pre-mRNA to promote its cleavage by the PA subunit. The resulting 11–13 capped oligomer is used by the...

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Bibliographic Details
Main Authors: Xiaolei Ma, Lili Xie, Charles Wartchow, Robert Warne, Yongjin Xu, Alexey Rivkin, David Tully, Steven Shia, Kyoko Uehara, Dianna M. Baldwin, Gladys Muiru, Weidong Zhong, Isabel Zaror, Dirksen E. Bussiere, Vincent H. J. Leonard
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-09538-x

Internet

https://doi.org/10.1038/s41598-017-09538-x

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