The Effect of Aerobic Training and Arbotin on Cardiac Nitric Oxide, Tumor Necrosis Factor alpha, and Vascular Endothelial Growth Factor in Male Diabetic Rats

Background and Objectives: Diabetes is one of the most important metabolic diseases, which its incidence rate has increased in recent years. In this disease, the insulin function is impaired, leading to several complications. Physical exercise and medicinal plants are considered as a way to control...

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Main Authors:	Rahemeh Jahangiri Jahangiri, Parvin Farzanegi, Masoumeh Habibian Habibian
Format:	Article
Language:	fas
Published:	Qom University of Medical Sciences 2017-07-01
Series:	Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum
Subjects:	exercise arbotin nitric oxide tumor necrosis factor-alpha vascular endothelial growth factor a diabetes mellitus
Online Access:	http://journal.muq.ac.ir/browse.php?a_code=A-10-47-8&slc_lang=en&sid=1

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spelling	doaj-0e8cb26ae0c0455c8f437e8595190fb72021-08-31T09:33:27ZfasQom University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum1735-77992008-13752017-07-011155362The Effect of Aerobic Training and Arbotin on Cardiac Nitric Oxide, Tumor Necrosis Factor alpha, and Vascular Endothelial Growth Factor in Male Diabetic RatsRahemeh Jahangiri Jahangiri0Parvin Farzanegi1Masoumeh Habibian Habibian2 Department of Exercise Physiology, Faculty of Humanities, Sari Branch, Islamic Azad University, Sari, Iran. Department of Exercise Physiology, Faculty of Humanities, Sari Branch, Islamic Azad University, Sari, Iran. 2Department of Physical Education, Qaemshahar Branch, Islamic Azad University, Qaemshahar, Iran. Background and Objectives: Diabetes is one of the most important metabolic diseases, which its incidence rate has increased in recent years. In this disease, the insulin function is impaired, leading to several complications. Physical exercise and medicinal plants are considered as a way to control diabetes along with nutrition and medicine. The present study was conducted with the purpose of determining the effect of aerobic training and use of arbutin on cardiac nitric oxide, tumor necrosis factor-α and vessel endothelial growth factor in male diabetic rats. Methods: In this experimental study, 42 male adult Wistar rats (age, 8 weeks; weight, 190-220g), were randomly divided into 6 groups of 7 each (control, arbutin, diabetic, diabetic+training, diabetic+arbutin, and diabetic+training+arbutin). Training programs included 5 days of swimming per week for 6 weeks. Sampling from the heart was performed 72 hours after the last training session and arbutin consumption to analyze NO, TNF-α and VEGF. Data were analyzed using one-way ANOVA at the significance level p≤0.05. Results: Aerobic training along with use of arbutin led to increased levels of NO and VEGF and decreased level of TNF-α in cardiac tissue of diabetic rats (p<0.001). Conclusion: The results indicated that a period of regular aerobic training and use of arbutin can be considered as an appropriate non-medicinal method to control diabetes mellitus type 2 through decrease in inflammatory factors.http://journal.muq.ac.ir/browse.php?a_code=A-10-47-8&slc_lang=en&sid=1 exercise arbotin nitric oxide tumor necrosis factor-alpha vascular endothelial growth factor a diabetes mellitus
collection	DOAJ
language	fas
format	Article
sources	DOAJ
author	Rahemeh Jahangiri Jahangiri Parvin Farzanegi Masoumeh Habibian Habibian
spellingShingle	Rahemeh Jahangiri Jahangiri Parvin Farzanegi Masoumeh Habibian Habibian The Effect of Aerobic Training and Arbotin on Cardiac Nitric Oxide, Tumor Necrosis Factor alpha, and Vascular Endothelial Growth Factor in Male Diabetic Rats Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum exercise arbotin nitric oxide tumor necrosis factor-alpha vascular endothelial growth factor a diabetes mellitus
author_facet	Rahemeh Jahangiri Jahangiri Parvin Farzanegi Masoumeh Habibian Habibian
author_sort	Rahemeh Jahangiri Jahangiri
title	The Effect of Aerobic Training and Arbotin on Cardiac Nitric Oxide, Tumor Necrosis Factor alpha, and Vascular Endothelial Growth Factor in Male Diabetic Rats
title_short	The Effect of Aerobic Training and Arbotin on Cardiac Nitric Oxide, Tumor Necrosis Factor alpha, and Vascular Endothelial Growth Factor in Male Diabetic Rats
title_full	The Effect of Aerobic Training and Arbotin on Cardiac Nitric Oxide, Tumor Necrosis Factor alpha, and Vascular Endothelial Growth Factor in Male Diabetic Rats
title_fullStr	The Effect of Aerobic Training and Arbotin on Cardiac Nitric Oxide, Tumor Necrosis Factor alpha, and Vascular Endothelial Growth Factor in Male Diabetic Rats
title_full_unstemmed	The Effect of Aerobic Training and Arbotin on Cardiac Nitric Oxide, Tumor Necrosis Factor alpha, and Vascular Endothelial Growth Factor in Male Diabetic Rats
title_sort	effect of aerobic training and arbotin on cardiac nitric oxide, tumor necrosis factor alpha, and vascular endothelial growth factor in male diabetic rats
publisher	Qom University of Medical Sciences
series	Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum
issn	1735-7799 2008-1375
publishDate	2017-07-01
description	Background and Objectives: Diabetes is one of the most important metabolic diseases, which its incidence rate has increased in recent years. In this disease, the insulin function is impaired, leading to several complications. Physical exercise and medicinal plants are considered as a way to control diabetes along with nutrition and medicine. The present study was conducted with the purpose of determining the effect of aerobic training and use of arbutin on cardiac nitric oxide, tumor necrosis factor-α and vessel endothelial growth factor in male diabetic rats. Methods: In this experimental study, 42 male adult Wistar rats (age, 8 weeks; weight, 190-220g), were randomly divided into 6 groups of 7 each (control, arbutin, diabetic, diabetic+training, diabetic+arbutin, and diabetic+training+arbutin). Training programs included 5 days of swimming per week for 6 weeks. Sampling from the heart was performed 72 hours after the last training session and arbutin consumption to analyze NO, TNF-α and VEGF. Data were analyzed using one-way ANOVA at the significance level p≤0.05. Results: Aerobic training along with use of arbutin led to increased levels of NO and VEGF and decreased level of TNF-α in cardiac tissue of diabetic rats (p<0.001). Conclusion: The results indicated that a period of regular aerobic training and use of arbutin can be considered as an appropriate non-medicinal method to control diabetes mellitus type 2 through decrease in inflammatory factors.
topic	exercise arbotin nitric oxide tumor necrosis factor-alpha vascular endothelial growth factor a diabetes mellitus
url	http://journal.muq.ac.ir/browse.php?a_code=A-10-47-8&slc_lang=en&sid=1
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The Effect of Aerobic Training and Arbotin on Cardiac Nitric Oxide, Tumor Necrosis Factor alpha, and Vascular Endothelial Growth Factor in Male Diabetic Rats

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