Cytomegalovirus Infection Mimicking Recurrence of Malignant Lymphoma: A Case Report
When a patient with malignant lymphoma develops new lymph node enlargement, a recurrence of lymphoma is usually suspected first. However, painless and rapid lymph node enlargement, a manifestation of non-Hodgkin’s lymphoma, could also be due to other causes. A 3-year-old boy who was previously diagn...
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The Korean Society of Pediatric Hematology-Oncology
2021-04-01
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doaj-0e8960d0d38d43e1ab4af43809dc51212021-04-30T08:18:43ZengThe Korean Society of Pediatric Hematology-OncologyClinical Pediatric Hematology-Oncology2233-52502021-04-01281586210.15264/cpho.2021.28.1.58cpho.2021.28.1.58Cytomegalovirus Infection Mimicking Recurrence of Malignant Lymphoma: A Case ReportSae-Mee Park0Young Bae Choi1Joon Kee Lee2Department of Pediatrics, Chungbuk National University Hospital, Cheongju, KoreaDepartment of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, Suwon, KoreaDepartment of Pediatrics, Chungbuk National University Hospital, Cheongju, KoreaWhen a patient with malignant lymphoma develops new lymph node enlargement, a recurrence of lymphoma is usually suspected first. However, painless and rapid lymph node enlargement, a manifestation of non-Hodgkin’s lymphoma, could also be due to other causes. A 3-year-old boy who was previously diagnosed with Burkitt lymphoma was admitted for routine tumor evaluation one year following completion of treatment. Abdominal computed tomography showed several enlarged lymph nodes in the right lower quadrant, and 18F-fluoro-2-deoxy-D-glucose positron emission tomography revealed hypermetabolic enlarged lymph nodes in the corresponding lesion. The patient underwent ileocecal lymph node biopsy for pathologic confirmation, which revealed reactive hyperplasia without lymphoma recurrence. Serologic test results for cytomegalovirus immunoglobulin G and immunoglobulin M were positive. Additionally, the polymerase chain reaction test performed using a urine sample was positive for cytomegalovirus. After several outpatient follow-ups, we concluded cytomegalovirus infection that mimicked a recurrence of lymphoma on imaging as the cause for lymph node enlargements. This case highlights the importance of using prompt and multiple approaches after detecting a possible tumor recurrence through imaging studies.https://doi.org/10.15264/cpho.2021.28.1.58burkitt lymphomacytomegalovirusdiagnostic imagingneoplasm recurrenceviral infections |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sae-Mee Park Young Bae Choi Joon Kee Lee |
spellingShingle |
Sae-Mee Park Young Bae Choi Joon Kee Lee Cytomegalovirus Infection Mimicking Recurrence of Malignant Lymphoma: A Case Report Clinical Pediatric Hematology-Oncology burkitt lymphoma cytomegalovirus diagnostic imaging neoplasm recurrence viral infections |
author_facet |
Sae-Mee Park Young Bae Choi Joon Kee Lee |
author_sort |
Sae-Mee Park |
title |
Cytomegalovirus Infection Mimicking Recurrence of Malignant Lymphoma: A Case Report |
title_short |
Cytomegalovirus Infection Mimicking Recurrence of Malignant Lymphoma: A Case Report |
title_full |
Cytomegalovirus Infection Mimicking Recurrence of Malignant Lymphoma: A Case Report |
title_fullStr |
Cytomegalovirus Infection Mimicking Recurrence of Malignant Lymphoma: A Case Report |
title_full_unstemmed |
Cytomegalovirus Infection Mimicking Recurrence of Malignant Lymphoma: A Case Report |
title_sort |
cytomegalovirus infection mimicking recurrence of malignant lymphoma: a case report |
publisher |
The Korean Society of Pediatric Hematology-Oncology |
series |
Clinical Pediatric Hematology-Oncology |
issn |
2233-5250 |
publishDate |
2021-04-01 |
description |
When a patient with malignant lymphoma develops new lymph node enlargement, a recurrence of lymphoma is usually suspected first. However, painless and rapid lymph node enlargement, a manifestation of non-Hodgkin’s lymphoma, could also be due to other causes. A 3-year-old boy who was previously diagnosed with Burkitt lymphoma was admitted for routine tumor evaluation one year following completion of treatment. Abdominal computed tomography showed several enlarged lymph nodes in the right lower quadrant, and 18F-fluoro-2-deoxy-D-glucose positron emission tomography revealed hypermetabolic enlarged lymph nodes in the corresponding lesion. The patient underwent ileocecal lymph node biopsy for pathologic confirmation, which revealed reactive hyperplasia without lymphoma recurrence. Serologic test results for cytomegalovirus immunoglobulin G and immunoglobulin M were positive. Additionally, the polymerase chain reaction test performed using a urine sample was positive for cytomegalovirus. After several outpatient follow-ups, we concluded cytomegalovirus infection that mimicked a recurrence of lymphoma on imaging as the cause for lymph node enlargements. This case highlights the importance of using prompt and multiple approaches after detecting a possible tumor recurrence through imaging studies. |
topic |
burkitt lymphoma cytomegalovirus diagnostic imaging neoplasm recurrence viral infections |
url |
https://doi.org/10.15264/cpho.2021.28.1.58 |
work_keys_str_mv |
AT saemeepark cytomegalovirusinfectionmimickingrecurrenceofmalignantlymphomaacasereport AT youngbaechoi cytomegalovirusinfectionmimickingrecurrenceofmalignantlymphomaacasereport AT joonkeelee cytomegalovirusinfectionmimickingrecurrenceofmalignantlymphomaacasereport |
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1721498198791421952 |