Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles
Cells that constitute the dermal papillae of hair follicles might be derived from the dermal sheath, the peribulbar component of which is the dermal sheath cup. The dermal sheath cup is thought to include the progenitor cells of the dermal papillae and possesses hair inductive potential; however, it...
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Society for Publication of Acta Dermato-Venereologica
2018-05-01
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| Series: | Acta Dermato-Venereologica |
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https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2949
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doaj-0e883f163f9c496d838789c3786553e02020-11-24T21:34:16ZengSociety for Publication of Acta Dermato-VenereologicaActa Dermato-Venereologica0001-55551651-20572018-05-0198769469810.2340/00015555-29495220Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair FolliclesShiro Niiyama0Yumiko Ishimatsu-TsujiYosuke NakazawaYuzo YoshidaTsutomu SomaRitsuro IdetaHideki MukaiJiro Kishimoto Department of Dermatology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-ku, Tokyo, 153-8515, Japan. sniiyama@aol.com. Cells that constitute the dermal papillae of hair follicles might be derived from the dermal sheath, the peribulbar component of which is the dermal sheath cup. The dermal sheath cup is thought to include the progenitor cells of the dermal papillae and possesses hair inductive potential; however, it has not yet been well characterized. This study investigated the gene expression profile of the intact dermal sheath cup, and identified dermal sheath cup signature genes, including extracellular matrix components and bone morphogenetic protein-binding molecules, as well as transforming frowth factor beta 1 as an upstream regulator. Among these, gremilin-2, a member of the bone morphogenetic protein antagonists, was found by in situ hybridization to be highly specific to the dermal sheath cup, implying that gremlin-2 is a key molecule contributing to maintenance of the properties of the dermal sheath cup. https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2949 alopeciadermalpapillaGREM2hairbiologyTGF-b1. |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Shiro Niiyama Yumiko Ishimatsu-Tsuji Yosuke Nakazawa Yuzo Yoshida Tsutomu Soma Ritsuro Ideta Hideki Mukai Jiro Kishimoto |
| spellingShingle |
Shiro Niiyama Yumiko Ishimatsu-Tsuji Yosuke Nakazawa Yuzo Yoshida Tsutomu Soma Ritsuro Ideta Hideki Mukai Jiro Kishimoto Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles Acta Dermato-Venereologica alopecia dermalpapilla GREM2 hairbiology TGF-b1. |
| author_facet |
Shiro Niiyama Yumiko Ishimatsu-Tsuji Yosuke Nakazawa Yuzo Yoshida Tsutomu Soma Ritsuro Ideta Hideki Mukai Jiro Kishimoto |
| author_sort |
Shiro Niiyama |
| title |
Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles |
| title_short |
Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles |
| title_full |
Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles |
| title_fullStr |
Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles |
| title_full_unstemmed |
Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles |
| title_sort |
gene expression profiling of the intact dermal sheath cup of human hair follicles |
| publisher |
Society for Publication of Acta Dermato-Venereologica |
| series |
Acta Dermato-Venereologica |
| issn |
0001-5555 1651-2057 |
| publishDate |
2018-05-01 |
| description |
Cells that constitute the dermal papillae of hair follicles might be derived from the dermal sheath, the peribulbar component of which is the dermal sheath cup. The dermal sheath cup is thought to include the progenitor cells of the dermal papillae and possesses hair inductive potential; however, it has not yet been well characterized. This study investigated the gene expression profile of the intact dermal sheath cup, and identified dermal sheath cup signature genes, including extracellular matrix components and bone morphogenetic protein-binding molecules, as well as transforming frowth factor beta 1 as an upstream regulator. Among these, gremilin-2, a member of the bone morphogenetic protein antagonists, was found by in situ hybridization to be highly specific to the dermal sheath cup, implying that gremlin-2 is a key molecule contributing to maintenance of the properties of the dermal sheath cup. |
| topic |
alopecia dermalpapilla GREM2 hairbiology TGF-b1. |
| url |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2949
|
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