Preclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration

Preclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration

Arthroplasty is the main clinical option for the treatment of osteoarticular lesions, but has limited efficacy. Here, the authors use a wound dressing with autologous mesenchymal stromal cells, functionalised for local BMP2 delivery, and show feasibility and safety in standardised preclinical tests...

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Bibliographic Details
Main Authors: Laetitia Keller, Luc Pijnenburg, Ysia Idoux-Gillet, Fabien Bornert, Laila Benameur, Maryam Tabrizian, Pierrick Auvray, Philippe Rosset, Rosa María Gonzalo-Daganzo, Enrique Gómez Barrena, Luca Gentile, Nadia Benkirane-Jessel
Format: Article
Language:English
Published: Nature Publishing Group 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10165-5
Description
Summary:Arthroplasty is the main clinical option for the treatment of osteoarticular lesions, but has limited efficacy. Here, the authors use a wound dressing with autologous mesenchymal stromal cells, functionalised for local BMP2 delivery, and show feasibility and safety in standardised preclinical tests in animal models, suggesting suitability for use in clinical trials.
ISSN:2041-1723

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