Organocatalytic asymmetric N-sulfonyl amide C-N bond activation to access axially chiral biaryl amino acids
Asymmetric activation of amide bonds remains a challenge due to the high stability of amide linkages. Here, the authors show an organocatalytic asymmetric C-N bond cleavage of N-sulfonyl biaryl lactams under mild conditions, to access axially chiral biaryl amino acids.
Bibliographic Details
| Main Authors: |
Guanjie Wang,
Qianqian Shi,
Wanyao Hu,
Tao Chen,
Yingying Guo,
Zhouli Hu,
Minghua Gong,
Jingcheng Guo,
Donghui Wei,
Zhenqian Fu,
Wei Huang |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-14799-8
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