Immunization with Bacillus Calmette-Guérin (BCG) alleviates neuroinflammation and cognitive deficits in APP/PS1 mice via the recruitment of inflammation-resolving monocytes to the brain

Immunization with Bacillus Calmette-Guérin (BCG) alleviates neuroinflammation and cognitive deficits in APP/PS1 mice via the recruitment of inflammation-resolving monocytes to the brain

The immune system plays a crucial role in the progression of Alzheimer's disease (AD). Recently, immune-dependent cascade induced by systemic immune activation has been verified to play a beneficial role in AD mouse models. Here, we tested whether Bacillus Calmette-Guérin (BCG) immunization alt...

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Bibliographic Details
Main Authors: Zejie Zuo, Fangfang Qi, Junhua Yang, Xiao Wang, Yingying Wu, Yaru Wen, Qunfang Yuan, Juntao Zou, Kaihua Guo, Zhi Bin Yao
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Neurobiology of Disease
Subjects:
BCG
Vaccination
AD
Monocytes
IFN-γ
Anti-inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611730030X

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http://www.sciencedirect.com/science/article/pii/S096999611730030X

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