Tumor Microenvironment as A “Game Changer” in Cancer Radiotherapy

Tumor Microenvironment as A “Game Changer” in Cancer Radiotherapy

Radiotherapy (RT), besides cancer cells, also affects the tumor microenvironment (TME): tumor blood vessels and cells of the immune system. It damages endothelial cells and causes radiation-induced inflammation. Damaged vessels inhibit the infiltration of CD8+ T lymphocytes into tumors, and immunosu...

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Bibliographic Details
Main Authors: Magdalena Jarosz-Biej, Ryszard Smolarczyk, Tomasz Cichoń, Natalia Kułach
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:International Journal of Molecular Sciences
Subjects:
tumor microenvironment
radiotherapy
“in situ” vaccination
immunosuppression
tumor vasculature
hypoxia
radioresistance
Online Access:https://www.mdpi.com/1422-0067/20/13/3212

Internet

https://www.mdpi.com/1422-0067/20/13/3212

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