Sulodexide. Nephroprotective properties and horizons for use in nephrology
Sulodexide belongs to the class of glycosaminoglycans (GAGs) or mucopolysaccharides. Found in mammalian tissuesm, GAGs regulate the activity of a wide range of proteins (including chemokines, cytokines, growth factors, enzymes, morphogens, and adhesion molecules). GAGs are large, linear, frequently...
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2015-12-01
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| Series: | Медицинский совет |
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| Online Access: | https://www.med-sovet.pro/jour/article/view/215 |
| Summary: | Sulodexide belongs to the class of glycosaminoglycans (GAGs) or mucopolysaccharides. Found in mammalian tissuesm, GAGs regulate the activity of a wide range of proteins (including chemokines, cytokines, growth factors, enzymes, morphogens, and adhesion molecules). GAGs are large, linear, frequently sulfated, negatively charged polysaccharides with a molecular weight ranging 1-2,000 kDa. They are organized as repetitions of disaccharide units of an uronic acid (D-glucuronic acid or L-iduronic acid) and an acetylated amino sugar (N-acetylgalactosamine or N-acetylglucosamine) either sulfated or non-sulfated. [5] The position of sulfation of GAGs is widely variable depending on their cell and tissue localization. GAGs exist both as part of proteoglycans and as free chains. Non-sulfated GAGs include hyaluronic acid and sulfated GAGs include chondroitin sulfate, dermatan sulfate, keratan sulfate, heparin, and heparan sulfate. |
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| ISSN: | 2079-701X 2658-5790 |