Potential Relevance of Bell-Shaped and U-Shaped Dose-Responses for the Therapeutic Targeting of Angiogenesis in Cancer
Tumor angiogenesis, the growth of new blood vessels into tumors, facilitates tumor growth and thus represents an attractive therapeutic target. Numerous experimental angiogenesis inhibitors have been characterised and subsequently trialled in patients. Some of these agents have failed to show any su...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2010-07-01
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| Series: | Dose-Response |
| Online Access: | https://doi.org/10.2203/dose-response.09-049.Reynolds |