Clinical and biomarker changes in premanifest Huntington disease show trial feasibility: a decade of the PREDICT-HD study

Clinical and biomarker changes in premanifest Huntington disease show trial feasibility: a decade of the PREDICT-HD study

There is growing consensus that intervention and treatment of Huntington disease (HD) should occur at the earliest stage possible. Various early-intervention methods for this fatal neurodegenerative disease have been identified, but preventive clinical trials for HD are limited by a lack of knowledg...

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Bibliographic Details
Main Authors: Jane S Paulsen, Jeffrey D Long, Hans J Johnson, Elizabeth H Aylward, Christopher A Ross, Janet K Williams, Martha A Nance, Cheryl J Erwin, Holly K Westervelt, Deborah Lynn Harrington, H Jeremy Bockholt, Ying eZhang, Elizabeth A McCusker, Edmund M Chiu, Peter K Panegyres
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
Huntington Disease
Natural History
clinical trials
Neurodegenerative disorders
outcome measures
premanifest
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00078/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00078/full

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