Effect of spatial inhomogeneities on the membrane surface on receptor dimerization and signal initiation

Important signal transduction pathways originate on the plasma membrane, where microdomains may transiently entrap diffusing receptors. This results in a non-random distribution of receptors even in the resting state, which can be visualized as clusters by high resolution imaging methods. Here, we...

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Bibliographic Details
Main Authors: Romica Kerketta, Adam Halasz, Mara P. Steinkamp, Bridget S. Wilson, Jeremy S. Edwards
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00081/full