Adenosine Receptor Agonists Increase the Inhibition of Platelet Function by P2Y<sub>12</sub> Antagonists in a cAMP- and Calcium-Dependent Manner

Adenosine Receptor Agonists Increase the Inhibition of Platelet Function by P2Y<sub>12</sub> Antagonists in a cAMP- and Calcium-Dependent Manner

We have shown previously that platelet activity can be lowered through the simultaneous inhibition of P2Y<sub>12</sub> receptor and activation of adenosine receptors (AR). This work explores this concept by testing the antiplatelet potential of nine AR agonists in combination with P2Y<...

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Bibliographic Details
Main Authors: Nina Wolska, Hassan Kassassir, Boguslawa Luzak, Cezary Watala, Marcin Rozalski
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Pharmaceuticals
Subjects:
platelet
adenosine receptor
adenosine receptor agonist
P2Y<sub>12</sub> antagonist
anti-platelet therapy
Online Access:https://www.mdpi.com/1424-8247/13/8/177

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