A selected small molecule prevents inflammatory osteolysis through restraining osteoclastogenesis by modulating PTEN activity

A selected small molecule prevents inflammatory osteolysis through restraining osteoclastogenesis by modulating PTEN activity

Abstract Background Inflammatory osteolysis is a severe infectious bone disorder that occurs during orthopaedic surgery and is caused by disruptions in the dynamic balance of bone matrix homeostasis, which makes this condition a burden on surgical procedures. Developing novel therapeutic drugs about...

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Bibliographic Details
Main Authors: Yueqi Chen, Wenhui Hu, Yiran Wang, Yuheng Li, Xiaoming Li, Haibo Li, Yong Tang, Lincheng Zhang, Yutong Dong, Xiaochao Yang, Ye Wei, Shiwu Dong
Format: Article
Language:English
Published: Wiley 2020-12-01
Series:Clinical and Translational Medicine
Subjects:
inflammatory osteolysis
osteoclastogenesis
PTEN
small molecule
Online Access:https://doi.org/10.1002/ctm2.240

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