Two Furanosesterterpenoids from the Sponge Luffariella variabilis

Two Furanosesterterpenoids from the Sponge Luffariella variabilis

Two new sesterterpenoids, 1 and 2, were isolated from the sponge Luffariella variabilis. Their planar structures were characterized with spectroscopic analyses. The sole chiral center of compound 1 was elucidated as 12R by comparing observed and calculated optical rotation values. The configurations...

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Bibliographic Details
Main Authors: Peni Ahmadi, Masahiro Higashi, Nicole J. de Voogd, Junichi Tanaka
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Marine Drugs
Subjects:
sesterterpenoid
sponge
cytotoxicity
Online Access:https://www.mdpi.com/1660-3397/15/8/249
Description
Summary:Two new sesterterpenoids, 1 and 2, were isolated from the sponge Luffariella variabilis. Their planar structures were characterized with spectroscopic analyses. The sole chiral center of compound 1 was elucidated as 12R by comparing observed and calculated optical rotation values. The configurations of compound 2 were determined by NMR and electronic circular dichroism (ECD) studies. Furthermore, compound 2 showed cytotoxicity at IC50 1.0 µM against NBT-T2 cells.
ISSN:1660-3397

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