Influx-Operated Ca2+ Entry via PKD2-L1 and PKD1-L3 Channels Facilitates Sensory Responses to Polymodal Transient Stimuli
The polycystic TRP subfamily member PKD2-L1, in complex with PKD1-L3, is involved in physiological responses to diverse stimuli. A major challenge to understanding whether and how PKD2-L1/PKD1-L3 acts as a bona fide molecular transducer is that recombinant channels usually respond with small or unde...
Main Authors: | Mingfeng Hu, Yuxia Liu, Jinzhi Wu, Xiaodong Liu |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2015-10-01
|
Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124715010669 |
Similar Items
-
Pkd1 and Pkd2 are required for normal placental development.
by: Miguel A Garcia-Gonzalez, et al.
Published: (2010-09-01) -
Structural basis for Ca2+ activation of the heteromeric PKD1L3/PKD2L1 channel
by: Qiang Su, et al.
Published: (2021-08-01) -
High Resolution Melt analysis for mutation screening in <it>PKD1 </it>and <it>PKD2 </it>
by: Fontes Michel, et al.
Published: (2011-10-01) -
PKD1 and PKD2 mutations in Slovenian families with autosomal dominant polycystic kidney disease
by: Adamlje Anton, et al.
Published: (2006-01-01) -
Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1
by: Qiang Su, et al.
Published: (2018-03-01)