Decoration of the enterococcal polysaccharide antigen EPA is essential for virulence, cell surface charge and interaction with effectors of the innate immune system.

Decoration of the enterococcal polysaccharide antigen EPA is essential for virulence, cell surface charge and interaction with effectors of the innate immune system.

Enterococcus faecalis is an opportunistic pathogen with an intrinsically high resistance to lysozyme, a key effector of the innate immune system. This high level of resistance requires a complex network of transcriptional regulators and several genes (oatA, pgdA, dltA and sigV) acting synergisticall...

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Main Authors: Robert E Smith, Bartłomiej Salamaga, Piotr Szkuta, Natalia Hajdamowicz, Tomasz K Prajsnar, Gregory S Bulmer, Thierry Fontaine, Justyna Kołodziejczyk, Jean-Marie Herry, Andrea M Hounslow, Mike P Williamson, Pascale Serror, Stéphane Mesnage
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-05-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007730

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