Evaluation of the evoked brain potentials of patients with asthenia and anxiety symptoms and the partial loss of sight

• Main Authors: Tsira Abdryakhimova, Rostislav Abdryakhimov, Andriy Snegir, Katherine Kleban, Inna Mukharovska
• Format: Article
• Language: English
• Published: Private Publisher "Chaban O.S." 2017-03-01
• Series: Psihosomatična Medicina ta Zagalʹna Praktika
• Online Access: https://e-medjournal.com/index.php/psp/article/view/26

Background. Loss of sight, even partial, especially in adulthood, is accompanied by emotional, motivational and social consequences that directly affect the psychophysiological state of the individual himself, his communication in society and, often, the social status of the subject.  Methods. From the group of patients-volunteers (n=15) with a partial loss of sight of traumatic genesis two groups were formed for carrying out neurophysiological studies: with predominant asthenia and predominant anxiety. The controle group (CG) constisted from patients of the same age (n=20) without psychiatric comorbidity. A study of acoustic event-related potentials of the brain (ERP) was carried out in the oddball paradigm with the recording of the time and correctness of a simple sensorimotor reaction. Results. Comparative analysis of the asthenia group with the comparison group revealed a sufficient number of indicators of the ERP, which have significant statistical differences. The correctness of the sensorimotor reaction in this group was 98.3 ± 2.44%, whereas in the CG - 92.5 ± 5.74% (U [15; 20] = 62.5, p <0.01). The values of the amplitude of the early positivity of P1 in the asthenia group were 4.25 ± 3.312 μV, and in the CG -4.15 ± 7.933 μV (U [15, 20] = 50, p <0.001). The early negativity in that group was -2.78 ± 2.377 μV, and in the CG it was 10.55 ± 7.466 μV (U [15; 20] = 75; p <0.05).  Conclusion. In the asthenia group this is the correctness of the sensorimotor reaction and the amplitude of the components: P1, N1, P2, N2. In the anxiety group, such indicators were: latency period P1, intervals P1N1 and N2P3, amplitude swing P1N1. A specific marker of the asthenia group, distinguishing it from the CG, was the more positive values of the amplitude of the components P1, N1, P2, N2. Taking into account the low-frequency nature of the modulation of the amplitudes of these components (circa 2 Hz), it can be assumed that nonspecific brainstem systems are involved in the process.