Design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement

Design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement

Synthetic molecular systems require subtle control over their thermodynamics and reaction kinetics to implement features such as catalysis. Here the authors propose using mismatches in a DNA duplex to drive catalytic reactions forward whilst maintaining tight catalytic control.

Bibliographic Details
Main Authors: Natalie E. C. Haley, Thomas E. Ouldridge, Ismael Mullor Ruiz, Alessandro Geraldini, Ard A. Louis, Jonathan Bath, Andrew J. Turberfield
Format: Article
Language:English
Published: Nature Publishing Group 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16353-y
Description
Summary:Synthetic molecular systems require subtle control over their thermodynamics and reaction kinetics to implement features such as catalysis. Here the authors propose using mismatches in a DNA duplex to drive catalytic reactions forward whilst maintaining tight catalytic control.
ISSN:2041-1723

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