Anti-Tumor Effects of MAPK-Dependent Tumor-Selective Oncolytic Vaccinia Virus Armed with CD/UPRT against Pancreatic Ductal Adenocarcinoma in Mice

Anti-Tumor Effects of MAPK-Dependent Tumor-Selective Oncolytic Vaccinia Virus Armed with CD/UPRT against Pancreatic Ductal Adenocarcinoma in Mice

Engineered vaccinia virus serves as an oncolytic virus for cancer virotherapy. We evaluated the oncolytic characteristics of <i>VGF</i>- and <i>O1</i>-deleted recombinant mitogen-activated protein kinase (MAPK)-dependent vaccinia virus (MDRVV). We found that compared with vir...

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Bibliographic Details
Main Authors: Hajime Kurosaki, Motomu Nakatake, Teruhisa Sakamoto, Nozomi Kuwano, Masato Yamane, Kenta Ishii, Yoshiyuki Fujiwara, Takafumi Nakamura
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
oncolytic vaccinia virus
MAPK pathway
antitumor effects
CD/UPRT
prodrug 5-FC
pancreatic cancer
Online Access:https://www.mdpi.com/2073-4409/10/5/985

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