Aluminium in Allergies and Allergen immunotherapy

Aluminium in Allergies and Allergen immunotherapy

Aluminium is a hot topic in the current debate. Exposure occurs due to environmental, dietary and intentional exposure to aluminium, such as in vaccines where it was introduced in 1926. In spite of the fact that it is a typical Th2 adjuvant, aluminium redirects the immune response in systemic allerg...

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Main Author: Erika Jensen-Jarolim
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:World Allergy Organization Journal
Online Access:http://www.sciencedirect.com/science/article/pii/S1939455119302066
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spelling doaj-0de40733c5184ffca0e92832df5339c52020-11-25T01:06:46ZengElsevierWorld Allergy Organization Journal1939-45512015-01-018Aluminium in Allergies and Allergen immunotherapyErika Jensen-Jarolim0Comparative Medicine, Messerli Research Institute, The University of Vet. Medicine Vienna, the Medical University Vienna, and the University Vienna, Währinger G. 18-20, 1090 Vienna, Austria; Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University Vienna, Vienna, Austria; Correspondence:Aluminium is a hot topic in the current debate. Exposure occurs due to environmental, dietary and intentional exposure to aluminium, such as in vaccines where it was introduced in 1926. In spite of the fact that it is a typical Th2 adjuvant, aluminium redirects the immune response in systemic allergen immunotherapy (SIT) upon prolonged immunization. SIT in the US, and SLIT in general, are at present non-adjuvanted therapies, but in Europe aluminium is used as adjuvant in most SIT preparations. It enhances the safety of SIT by local deposition of the allergen. Undesired properties of aluminium adjuvants comprise acute and chronic inflammation at the injection site, its Th2 immune stimulatory capacity, its accumulation besides biodistribution in the body. The adjuvant and safety profile of aluminium adjuvants in allergy vaccines are discussed, as well as the need for putting modern delivery systems and adjuvants on the fast track. Keywords: Allergen, Aluminium, Adjuvant, Allergen immunotherapy, Th2http://www.sciencedirect.com/science/article/pii/S1939455119302066
collection DOAJ
language English
format Article
sources DOAJ
author Erika Jensen-Jarolim
spellingShingle Erika Jensen-Jarolim
Aluminium in Allergies and Allergen immunotherapy
World Allergy Organization Journal
author_facet Erika Jensen-Jarolim
author_sort Erika Jensen-Jarolim
title Aluminium in Allergies and Allergen immunotherapy
title_short Aluminium in Allergies and Allergen immunotherapy
title_full Aluminium in Allergies and Allergen immunotherapy
title_fullStr Aluminium in Allergies and Allergen immunotherapy
title_full_unstemmed Aluminium in Allergies and Allergen immunotherapy
title_sort aluminium in allergies and allergen immunotherapy
publisher Elsevier
series World Allergy Organization Journal
issn 1939-4551
publishDate 2015-01-01
description Aluminium is a hot topic in the current debate. Exposure occurs due to environmental, dietary and intentional exposure to aluminium, such as in vaccines where it was introduced in 1926. In spite of the fact that it is a typical Th2 adjuvant, aluminium redirects the immune response in systemic allergen immunotherapy (SIT) upon prolonged immunization. SIT in the US, and SLIT in general, are at present non-adjuvanted therapies, but in Europe aluminium is used as adjuvant in most SIT preparations. It enhances the safety of SIT by local deposition of the allergen. Undesired properties of aluminium adjuvants comprise acute and chronic inflammation at the injection site, its Th2 immune stimulatory capacity, its accumulation besides biodistribution in the body. The adjuvant and safety profile of aluminium adjuvants in allergy vaccines are discussed, as well as the need for putting modern delivery systems and adjuvants on the fast track. Keywords: Allergen, Aluminium, Adjuvant, Allergen immunotherapy, Th2
url http://www.sciencedirect.com/science/article/pii/S1939455119302066
work_keys_str_mv AT erikajensenjarolim aluminiuminallergiesandallergenimmunotherapy
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