Prevention of non‐alcoholic steatohepatitis by long‐term exercise via the induction of phenotypic changes in Kupffer cells of hyperphagic obese mice

Prevention of non‐alcoholic steatohepatitis by long‐term exercise via the induction of phenotypic changes in Kupffer cells of hyperphagic obese mice

Abstract Exercise ameliorates nonalcoholic fatty liver disease (NAFLD) by inducing phenotypic changes in Kupffer cells (KCs). p62/Sqstm1‐knockout (p62‐KO) mice develop NAFLD alongside hyperphagia‐induced obesity. We evaluated (1) the effects of long‐term exercise on the foreign‐body phagocytic capac...

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Bibliographic Details
Main Authors: Ikuru Miura, Shoichi Komine, Kosuke Okada, Shota Wada, Eiji Warabi, Fumihiko Uchida, Sechang Oh, Hideo Suzuki, Yuji Mizokami, Junichi Shoda
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Physiological Reports
Subjects:
dehydroepiandrosterone
Kupffer cell
long‐term exercise
non‐alcoholic fatty liver disease
Online Access:https://doi.org/10.14814/phy2.14859

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