Genome of the fatal tapeworm Sparganum proliferum uncovers mechanisms for cryptic life cycle and aberrant larval proliferation

Kikuchi et al. sequence the genome of the fatal tapeworm Sparganum proliferum and a closely related non–life-threatening tapeworm Spirometra erinaceieuropaei, and describe its genomic features suggesting the natural history and molecular mechanisms underlying pathogenicity. Their findings indicate t...

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Main Authors:	Taisei Kikuchi, Mehmet Dayi, Vicky L. Hunt, Kenji Ishiwata, Atsushi Toyoda, Asuka Kounosu, Simo Sun, Yasunobu Maeda, Yoko Kondo, Belkisyole Alarcon de Noya, Oscar Noya, Somei Kojima, Toshiaki Kuramochi, Haruhiko Maruyama
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-05-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-021-02160-8

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spelling	doaj-0dd6f2e416d24802a0dc144cc251c86e2021-06-06T11:30:30ZengNature Publishing GroupCommunications Biology2399-36422021-05-014111210.1038/s42003-021-02160-8Genome of the fatal tapeworm Sparganum proliferum uncovers mechanisms for cryptic life cycle and aberrant larval proliferationTaisei Kikuchi0Mehmet Dayi1Vicky L. Hunt2Kenji Ishiwata3Atsushi Toyoda4Asuka Kounosu5Simo Sun6Yasunobu Maeda7Yoko Kondo8Belkisyole Alarcon de Noya9Oscar Noya10Somei Kojima11Toshiaki Kuramochi12Haruhiko Maruyama13Faculty of Medicine, University of MiyazakiFaculty of Medicine, University of MiyazakiDepartment of Biology and Biochemistry, University of BathDepartment of Tropical Medicine, The Jikei University School of MedicineComparative Genomics Laboratory, Department of Genomics and Evolutionary Biology, National Institute of Genetics, MishimaFaculty of Medicine, University of MiyazakiFaculty of Medicine, University of MiyazakiFaculty of Medicine, University of MiyazakiDivision of Medical Zoology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori UniversityInstitute of Tropical Medicine, Central University of Venezuela, MaracayInstitute of Tropical Medicine, Central University of Venezuela, MaracayDepartment of Clinical Laboratory Medicine, Chiba-Nishi General Hospital, Matsudo CityDepartment of Zoology, National Museum of Nature and Science, TsukubaFaculty of Medicine, University of MiyazakiKikuchi et al. sequence the genome of the fatal tapeworm Sparganum proliferum and a closely related non–life-threatening tapeworm Spirometra erinaceieuropaei, and describe its genomic features suggesting the natural history and molecular mechanisms underlying pathogenicity. Their findings indicate that nonordinal extracellular matrix coordination is important for its asexual reproduction, and suggest that loss of sexual maturity contributes to the fatal pathogenicity of S. proliferum to humans.https://doi.org/10.1038/s42003-021-02160-8
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Taisei Kikuchi Mehmet Dayi Vicky L. Hunt Kenji Ishiwata Atsushi Toyoda Asuka Kounosu Simo Sun Yasunobu Maeda Yoko Kondo Belkisyole Alarcon de Noya Oscar Noya Somei Kojima Toshiaki Kuramochi Haruhiko Maruyama
spellingShingle	Taisei Kikuchi Mehmet Dayi Vicky L. Hunt Kenji Ishiwata Atsushi Toyoda Asuka Kounosu Simo Sun Yasunobu Maeda Yoko Kondo Belkisyole Alarcon de Noya Oscar Noya Somei Kojima Toshiaki Kuramochi Haruhiko Maruyama Genome of the fatal tapeworm Sparganum proliferum uncovers mechanisms for cryptic life cycle and aberrant larval proliferation Communications Biology
author_facet	Taisei Kikuchi Mehmet Dayi Vicky L. Hunt Kenji Ishiwata Atsushi Toyoda Asuka Kounosu Simo Sun Yasunobu Maeda Yoko Kondo Belkisyole Alarcon de Noya Oscar Noya Somei Kojima Toshiaki Kuramochi Haruhiko Maruyama
author_sort	Taisei Kikuchi
title	Genome of the fatal tapeworm Sparganum proliferum uncovers mechanisms for cryptic life cycle and aberrant larval proliferation
title_short	Genome of the fatal tapeworm Sparganum proliferum uncovers mechanisms for cryptic life cycle and aberrant larval proliferation
title_full	Genome of the fatal tapeworm Sparganum proliferum uncovers mechanisms for cryptic life cycle and aberrant larval proliferation
title_fullStr	Genome of the fatal tapeworm Sparganum proliferum uncovers mechanisms for cryptic life cycle and aberrant larval proliferation
title_full_unstemmed	Genome of the fatal tapeworm Sparganum proliferum uncovers mechanisms for cryptic life cycle and aberrant larval proliferation
title_sort	genome of the fatal tapeworm sparganum proliferum uncovers mechanisms for cryptic life cycle and aberrant larval proliferation
publisher	Nature Publishing Group
series	Communications Biology
issn	2399-3642
publishDate	2021-05-01
description	Kikuchi et al. sequence the genome of the fatal tapeworm Sparganum proliferum and a closely related non–life-threatening tapeworm Spirometra erinaceieuropaei, and describe its genomic features suggesting the natural history and molecular mechanisms underlying pathogenicity. Their findings indicate that nonordinal extracellular matrix coordination is important for its asexual reproduction, and suggest that loss of sexual maturity contributes to the fatal pathogenicity of S. proliferum to humans.
url	https://doi.org/10.1038/s42003-021-02160-8
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Genome of the fatal tapeworm Sparganum proliferum uncovers mechanisms for cryptic life cycle and aberrant larval proliferation

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