Evasion of antiviral innate immunity by Theiler's virus L* protein through direct inhibition of RNase L.

Theiler's virus is a neurotropic picornavirus responsible for chronic infections of the central nervous system. The establishment of a persistent infection and the subsequent demyelinating disease triggered by the virus depend on the expression of L*, a viral accessory protein encoded by an alt...

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Bibliographic Details
Main Authors: Frédéric Sorgeloos, Babal Kant Jha, Robert H Silverman, Thomas Michiels
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3694852?pdf=render