Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and Functions

Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and Functions

Extrachromosomal circular DNA (eccDNA), existing as double-stranded circular DNA, is derived and free from chromosomes. It is common in eukaryotes but has a strong heterogeneity in count, length, and origin. It has been demonstrated that eccDNA could function in telomere and rDNA maintenance, aging,...

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Main Authors: Xiukai Cao, Shan Wang, Ling Ge, Weibo Zhang, Jinlin Huang, Wei Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Veterinary Science
Subjects:
eccDNA
microDNA
tumor
livestock
molecular marker
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2021.693641/full
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spelling doaj-0dcab2b0923443e49f44f03b5de9279b2021-09-09T09:09:05ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692021-09-01810.3389/fvets.2021.693641693641Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and FunctionsXiukai Cao0Shan Wang1Ling Ge2Weibo Zhang3Jinlin Huang4Wei Sun5Wei Sun6Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaJiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, ChinaJoint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaExtrachromosomal circular DNA (eccDNA), existing as double-stranded circular DNA, is derived and free from chromosomes. It is common in eukaryotes but has a strong heterogeneity in count, length, and origin. It has been demonstrated that eccDNA could function in telomere and rDNA maintenance, aging, drug resistance, tumorigenesis, and phenotypic variations of plants and animals. Here we review the current knowledge about eccDNA in category, biogenesis, recognition, and functions. We also provide perspectives on the potential implications of eccDNA in life science.https://www.frontiersin.org/articles/10.3389/fvets.2021.693641/fulleccDNAmicroDNAtumorlivestockmolecular marker
collection DOAJ
language English
format Article
sources DOAJ
author Xiukai Cao
Shan Wang
Ling Ge
Weibo Zhang
Jinlin Huang
Wei Sun
Wei Sun
spellingShingle Xiukai Cao
Shan Wang
Ling Ge
Weibo Zhang
Jinlin Huang
Wei Sun
Wei Sun
Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and Functions
Frontiers in Veterinary Science
eccDNA
microDNA
tumor
livestock
molecular marker
author_facet Xiukai Cao
Shan Wang
Ling Ge
Weibo Zhang
Jinlin Huang
Wei Sun
Wei Sun
author_sort Xiukai Cao
title Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and Functions
title_short Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and Functions
title_full Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and Functions
title_fullStr Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and Functions
title_full_unstemmed Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and Functions
title_sort extrachromosomal circular dna: category, biogenesis, recognition, and functions
publisher Frontiers Media S.A.
series Frontiers in Veterinary Science
issn 2297-1769
publishDate 2021-09-01
description Extrachromosomal circular DNA (eccDNA), existing as double-stranded circular DNA, is derived and free from chromosomes. It is common in eukaryotes but has a strong heterogeneity in count, length, and origin. It has been demonstrated that eccDNA could function in telomere and rDNA maintenance, aging, drug resistance, tumorigenesis, and phenotypic variations of plants and animals. Here we review the current knowledge about eccDNA in category, biogenesis, recognition, and functions. We also provide perspectives on the potential implications of eccDNA in life science.
topic eccDNA
microDNA
tumor
livestock
molecular marker
url https://www.frontiersin.org/articles/10.3389/fvets.2021.693641/full
work_keys_str_mv AT xiukaicao extrachromosomalcirculardnacategorybiogenesisrecognitionandfunctions
AT shanwang extrachromosomalcirculardnacategorybiogenesisrecognitionandfunctions
AT lingge extrachromosomalcirculardnacategorybiogenesisrecognitionandfunctions
AT weibozhang extrachromosomalcirculardnacategorybiogenesisrecognitionandfunctions
AT jinlinhuang extrachromosomalcirculardnacategorybiogenesisrecognitionandfunctions
AT weisun extrachromosomalcirculardnacategorybiogenesisrecognitionandfunctions
AT weisun extrachromosomalcirculardnacategorybiogenesisrecognitionandfunctions
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