Anti-Inflammatory Effect of Methylpenicinoline from a Marine Isolate of Penicillium sp. (SF-5995): Inhibition of NF-κB and MAPK Pathways in Lipopolysaccharide-Induced RAW264.7 Macrophages and BV2 Microglia

Anti-Inflammatory Effect of Methylpenicinoline from a Marine Isolate of Penicillium sp. (SF-5995): Inhibition of NF-κB and MAPK Pathways in Lipopolysaccharide-Induced RAW264.7 Macrophages and BV2 Microglia

In the course of a search for anti-inflammatory metabolites from marine-derived fungi, methylpenicinoline (1) was isolated from a marine isolate of Penicillin sp. Compound 1 inhibited lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production by suppressing the expression of inducible NO synth...

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Bibliographic Details
Main Authors: Dong-Cheol Kim, Hee-Suk Lee, Wonmin Ko, Dong-Sung Lee, Jae Hak Sohn, Joung Han Yim, Youn-Chul Kim, Hyuncheol Oh
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:Molecules
Subjects:
methylpenicinoline
Penicillium sp.
marine fungus
anti-inflammation
nuclear factor-kappa B (NF-κB)
mitogen-activated protein kinase (MAPK)
Online Access:http://www.mdpi.com/1420-3049/19/11/18073

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