Large-scale functional purification of recombinant HIV-1 capsid.

Large-scale functional purification of recombinant HIV-1 capsid.

During human immunodeficiency virus type-1 (HIV-1) virion maturation, capsid proteins undergo a major rearrangement to form a conical core that protects the viral nucleoprotein complexes. Mutations in the capsid sequence that alter the stability of the capsid core are deleterious to viral infectivit...

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Bibliographic Details
Main Authors: Magdeleine Hung, Anita Niedziela-Majka, Debi Jin, Melanie Wong, Stephanie Leavitt, Katherine M Brendza, Xiaohong Liu, Roman Sakowicz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3589475?pdf=render

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