The Antipsychotic and Antiemetic Drug Prochlorperazine Delays the Ventricular Repolarization of the In Situ Canine Heart

Electropharmacological effect of the antipsychotic and antiemetic drug prochlorperazine was assessed using the halothane-anesthetized in vivo canine model (n = 5). Up to 10 times higher than the clinically relevant doses of prochlorperazine (≤ 3mg/kg, i.v.) did not induce cardiohemodynamic collapse...

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Bibliographic Details
Main Authors: Yoshioki Satoh, Atsushi Sugiyama, Akira Takahara, Kentaro Ando, Kai Wang, Sachiko Honsho, Keitaro Hashimoto
Format: Article
Language:English
Published: Elsevier 2005-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319322996